There is not yet enough strong evidence, including comparative research using placebos, to make a case for microdosing.However, users report a few different benefits, which generally relate to mental health and well-being. A study in Harm Reduction Journal categorized several possible benefits from reports by microdosers. These benefits include:
- improved focus, concentration, and mindfulness
- improved energy, wakefulness, and stimulation
- cognitive benefits, such as enhanced problem solving
- social benefits
- reduced anxiety
- reduced symptoms, such as stress
- improved mood, optimism, and life appreciation
- improved body functioning
- self-efficacy, including improved ambition, productivity, and motivation
People also reported other benefits and enjoyments of microdosing, such as the ability to control the dose and the general lack of side effects.
Improved mental healthMany of the reasons why people microdose involve some aspects of mental health, such as reducing stress and anxiety or alleviating symptoms of depression. In a study in Psychopharmacology, researchers asked people their reasoning for microdosing. 21% of people responded that they primarily used microdosing as a therapy for depression, while 7% used microdosing for symptoms of anxiety. About 9% of people who responded used microdosing to help with other mental health disorders. Overall, 44% of people who responded perceived that their mental health was much better as a consequence of microdosing. Another study in Frontiers in Psychiatry used an online questionnaire to ask people who microdose to compare its effects with those of other treatments for symptoms such as depression and anxiety. The answers indicated that people found microdosing more effective than some other forms of treatment but less effective than higher doses of psychedelics.
In an animal study, researchers noted that microdose levels of DMT helped the subjects overcome fears and anxieties in a test that scientists commonly use to model issues such as post-traumatic stress disorder (PTSD) and general anxiety.More research in humans is necessary to support this early evidence.